There are various methods of induction of labor (IOL). One of the commonly used method is use of Misoprostol. However, with the use of Misoprostol alone, there are cases of failed IOL leading to operative deliveries. Another drug, Mifepristone has been shown to be effective in cervical ripening and induction of labor. So the aim of this study was to assess the effectiveness of Mifepristone as pre-treatment with misoprostol in induction of labor, thereby decreasing the rates of Caesarean section. This was a prospective comparative study where, one group receiving pre-treatment with Mifepristone 200mg orally 24 hours before Misoprostol and the other receiving only Misoprostol- 25mcg vaginally, maximum 2 doses 6 hours apart. The study was conducted in a period of 1 year at Patan Academy of Health and Sciences (PAHS), Nepal, which included 124 primigravidas. Fifty percent of women who underwent induction with Mifepristone+Misoprostol combination had vaginal deliveries, while 45% had emergency Lower Segment Caesarean section (LSCS) and 5% had instrumental deliveries. But, only 39% had vaginal deliveries in Misoprostol only group, with 56% LSCS and 5% instrumental deliveries. P value in the mode of delivery was not statistically significant (p>0.05). Failed IOL was commonly seen in Misoprostol only group (48%). The rate of failed IOL was 21% in Mifepristone+Misoprostol group, which was statistically significant (p=0.026). The mean induction-delivery time interval, was lower in Mifepristone+Misoprostol group (18.55 hours) than in Misoprostol only group (19.9 hours). Use of Mifepristone prior to Misoprostol decreases the caesarean section rates due to failed induction of labor.