The aim of the study is to evaluate the effective protective potential of aprepitant on L-arginine induced pancreatitis in albino wistar rats. Thirty albino wistar rats weighing 150-200 g were randomly divided into five groups. Each group contains six animals. Pancreatitis was induced by 250 mg L- Arginine in the normal saline and administer in the time interval of 4th, 7th, 10th, 13th, 16th and 19th days. Treatment with aprepitant 14 mg/kg and 8 mg/kg was evaluated by using body weight and serum parameters like amylase, lipase, creatinine, BUN, ALT, AST, inflammatory markers and histological study of pancreatitis induced rat’s pancreas. The present study demonstrates that treatment with aprepitant with 14 mg/kg and 8 mg/kg had potential therapeutic effects on the treatment of pancreatitis. It was found that parental administration of the aprepitant shows the equal effectiveness in treating pancreatitis when compared with pancreatic rats treated with standard drug methylprednisolone. Histopathological studies of the pancreas sample also confirmed the damage in the pancreas reduced due to the aprepitant. This shows good anti- inflammatory activity against diseased group. It is concluded that the aprepitant showed siginificant anti- inflammatory activity in albino rats. Among that aprepitant 14 mg/kg showed distinguished effect than aprepitant 8 mg/kg. Therefore, the study results show that the aprepitant produces siginificant suppression of inflammation, cell damage in pancreas. Thus, it has the potential to be developed for clinical applications in the future.