Maxillary lateral incisors agenesis (MLIA) is a common dental anomaly often managed through space opening to accommodate prosthetic replacement. This approach integrates orthodontic and prosthodontic techniques to restore function and aesthetics. This article explores advancements in space opening treatment, with an emphasis on prosthetic rehabilitation using implant and bridge, and highlights the role of digital dentistry in improving outcomes. Recent evidence-based studies provide insights into the clinical decision-making process and long-term success rates.