Six Sigma has developed as a powerful methodology in industrial engineering for improving process efficiency, reducing defects, and enhancing overall productivity. Established in statistical analysis and continuous improvement principles, Six Sigma provides a structured framework for identifying process variations and reducing inefficiencies. This research paper explores the application of Six Sigma methodologies in industrial engineering, focusing on its impact on quality control, cost reduction, and operational excellence. The study examines real-world case studies from manufacturing industries, highlighting successful implementations of Six Sigma tools such as DMAIC (Define, Measure, Analyze, Improve, Control) and DMADV (Define, Measure, Analyze, Design, Verify). Additionally, it discusses the integration of Six Sigma with lean manufacturing principles to optimize workflows and reduce waste. The findings emphasize the significance of Six Sigma in fostering a culture of continuous improvement, driving competitive advantage, and ensuring sustainable growth in industrial engineering. This paper determines with recommendations for industries aiming to implement Six Sigma for long-term operational success.