The variability in cement brands significantly influences the compressive strength of concrete, highlighting the need for a cost comparison to evaluate the economic implications of strength variations used for different purposes of buildings and infrastructure, this study was undertaken with the objective to evaluate and compare the compressive strength of M20-grade concrete prepared using various brands of Ordinary Portland Cement (OPC) 43 grade commonly used in the central terai region of Nepal. Additionally, the study aimed to establish a correlation between the cost and strength variations among ten different cement brands available in the market, providing insights into their economic and structural performance. This research provides valuable insights into the impact of various cement brands on the compressive strength of M20 grade concrete used in construction. The evidence-based findings of this study will assist construction professionals and the general public in making informed decisions, ultimately enhancing construction quality and ensuring structural integrity within the region.