New pharmaceuticals developed from the current medicinal plants can treat the ailment more successfully, potentially aiding the treatment, since a safer and more effective way may be discovered in the future. Nutritional value of medicinal plants and searching of novel compounds enhance the with therapeutic use in the different sectors. Secondary metabolites are created as byproducts or intermediates of secondary plant metabolism. Polymeric nanoparticles are colloidal structures that act to control the novel delivery of medications by guiding them to certain locations. Curcumin is one of the plant-based compounds with some medical potential. It a yellow polyphenol that typically targeted the cells of the viral particles. Ganoderma lucidum is a well-known treatment for hemiplegia and stroke. Nanoparticles are used in cancer diagnosis and therapy because of their ability to target tumours, deliver drugs, and boost the immune system. Among their advantages are their mucoadhesive, biocompatible, and biodegradable properties, as well as their multifunctional physicochemical properties that allow for site-specific targeting and allows the chemical modification. Nanoemulsions are currently appealing nanocarriers due to their ability to enhance the drug transport across bio-membranes, prolong the half-life in the body, and encapsulate medications with a high lipophilic aptitude. These days, nanoparticles provide a vast array of biological applications or an expanded the different fields.