Automated equipment has many benefits but analytical assessment of instrument is required for laboratory usage. This study evaluates the performance of Sysmex XN-50 slide-maker and stainer compared to manual technique. The primary goal of the study was to evaluate smear’s quality. Additionally, carry-over, repeatability, comparability using Passing Bablok Regression for white blood cells then sensitivity and specificity for red blood cells and platelets. Smear’s quality was acceptable except for one. There was no carry-over on the Sysmex XN50. Repeatability showed acceptable results. There was good agreement on white blood cells differential count including abnormal cells between blood films by the Sysmex XN50 and manually prepared blood films. Red blood cells and platelets were also comparable, the results were excellent, with sensitivity and specificity being very high. The results obtained in this study show the quality of the Sysmex XN50 device in a laboratory, it offers advantages due to its reliability and speed of preparation of blood smears.