Sepsis is a life-threatening condition resulting from an extreme immune response to infection, leading to organ dysfunction and high mortality rates. Early identification and timely intervention are crucial for improving patient outcomes. This review explores evidence-based strategies in sepsis management, including early recognition, fluid resuscitation, antimicrobial therapy, hemodynamic support, and nursing interventions. The role of a multidisciplinary healthcare team in sepsis care is also highlighted, emphasizing the importance of adherence to international guidelines such as the Surviving Sepsis Campaign. Strengthening nursing protocols and adopting advanced monitoring techniques can significantly reduce sepsis-related morbidity and mortality.