Menopause marks a significant transition in a woman's life, characterized by the cessation of menstruation and reproductive capabilities. This review examines post-menopausal quality of life (QoL) indicators across physical, psychological, sexual, and social dimensions. Challenges such as vasomotor symptoms, mood fluctuations, and sexual dysfunction are prevalent. However, interventions including lifestyle changes, healthcare support, and psychosocial strategies can enhance the overall experience of post-menopausal women. Understanding these determinants is critical for healthcare professionals to meet women's needs and improve outcomes during this phase.