Aim and Background: This systematic review aimed to investigate the efficacy of photobiomodulation (PBM) on alleviating orthodontic pain. Review Methods: An extensive electronic search for randomized control trials via Medline (via PubMed), The Cochrane Controlled Clinical Trials Register, and Science Direct up to October 15, 2023 was done. Hand searching was performed for relevant journals. Reference articles were retrieved and exported to Zotero software. The risk of bias was assessed using Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2). Results: A total of 8 articles were considered for systematic review. Most of the studies arrived at the consensus that photobiomodulation (PBM) indeed reduces the pain associated with orthodontic treatments. Conclusion: The synthesis of available evidence in our analysis reveals a substantial body of research suggesting a positive effect of PBM on reducing orthodontic pain. However, the existing variations in PBM parameters, and outcome measurements emphasize the necessity for more standardized approaches in future investigations.