Aim of the study: To assess the attitude and knowledge among Yemeni parents toward their child’s oral health practice and habits with associated factors. Subjects and methods: This study was carried out using three hundred self-administered structured questionnaires for parents or guardians. Demographic variables, knowledge of dental health, oral health, and dietary practices concerning dental care, and attitudes toward oral health were assessed. The correlation between sociodemographic status and oral health knowledge and practice was evaluated. Result: results showed that the mean caregiver's level of knowledge is 53.9%. Most mothers have good knowledge about the age of primary teeth eruption 71.9% and exfoliation 64.9%, the significance of primary teeth 78.4%, what causes the most common dental disease affects teeth 91.8%, and the importance of cleaning teeth 85.4%. 68.4% Cleaned their teeth, and most of them 78.4% remained to encourage their children to clean their teeth. Mothers have bad knowledge about the time to start brushing their children’s teeth 46.8% and the role of fluoride in preventing dental caries 32.2%. There was a statistically significant correlation between the level of knowledge and the mother’s education level and occupation. Conclusion: Yemeni mothers have average knowledge of their children’s oral health status. There was a statistically significant relation between the mother’s education level and the level of knowledge. The mother's education level group (Professional) ranked first with a knowledge level (73%).