Background: Enteral feeding intolerance (EFI) is a critical concern in critically ill patients, associated with complications like vomiting, elevated gastric residual volumes (GRV), and delayed gastric emptying. Despite its prevalence, EFI lacks a universally accepted definition and standardized management protocols, leading to inconsistent practices among healthcare providers. Aim: This study aimed to evaluate nurses’ knowledge at Ibri Hospital regarding EFI, including its definition, causes, symptoms, and the feasibility of oral medication administration during intolerance episodes. Evidence-based recommendations were proposed to improve enteral feeding practices. Methods: A cross-sectional descriptive design was used, involving 170 nurses from inpatient departments at Ibri Hospital. Data were collected via a validated online questionnaire and analyzed using SPSS. Key knowledge areas assessed included EFI indicators, GRV thresholds, and clinical management practices. Convenience sampling was employed. Results: The study revealed variability in nurses’ understanding of EFI indicators and GRV thresholds. Vomiting was the most recognized EFI indicator, though only 62% identified it correctly. GRV threshold knowledge varied, with 61% selecting context-dependent measurements. Pediatric ward nurses demonstrated the highest knowledge, while operating theater staff scored the lowest. Training had minimal impact, except for improved recognition of vomiting as an indicator (p = 0.025). Nurses favoring early feeding initiation and timely restarting showed higher knowledge scores. Conclusions: Significant knowledge gaps and inconsistencies in EFI practices were identified. Recommendations include developing evidence-based EFI protocols, regular interdisciplinary training, and promoting collaborative decision-making. Future research should validate findings and assess the impact of standardized EFI protocols on patient outcomes.