Worldwide, infertility is a prevalent problem that poses a threat to couples, either the male or female partner, or both spouses, may be the cause of infertility. Numerous elements about the patient's general health or way of life may be to blame. Systemic or gonadal dysfunction may be the cause of the patient's health issues. Hematological factors may be one of the systemic reasons. Thalassemia major (TM) and sickle cell disease (SCD) are the two most prevalent hemoglobinopathies that are suspected to be the cause of infertility, particularly male infertility. Through pathophysiological changes, these two hemoglobinopathies result in male infertility. In particular, they change red blood cells' (RBCs') capacity to carry oxygen, resulting in tissue hypoxia that impacts spermatogenesis and the body's natural process of producing new cells, ultimately leading to infertility. Semen analyses and other systemic blood testing can be used to investigate male infertility. Both hemoglobinopathies can be helped by blood transfusions, which can then alleviate male infertility. This paper aims to explore the relationship between hemoglobinopathies (SCD and TM) and their role in contributing to male infertility, in addition to the role of blood transfusions in addressing male infertility by correcting the root cause.