Agriculture and rural areas play an important role in the economy and the stable development of society. Along with the country's innovation process after the mistakes and limitations of the planning mechanism and centralized subsidies, our country has entered a period of stability, development and integration with the world. An Giang is a key province in agricultural production in the Mekong Delta and the whole country. The achievements of the renovation process have promoted positivity and created personal motivation for people to promote creativity in agricultural production, contributing to raising and improving life, escaping the situation of food shortage, abandoned land and damaged agricultural tools. However, An Giang in particular and the Mekong Delta provinces in general are facing challenges due to climate change, water scarcity and saline intrusionex, cessive crop growth, along with flood control dykes, has made the land inhospitable, excessive use of chemical fertilizers and pesticides has led to serious environmental pollution, ecosystem destruction, and biodiversity changes over hundreds of years, affecting people's health and causing many new diseases, especially cancer. Therefore, changing the way of production, following nature, towards ecological and sustainable agriculture for a clean environment and public health is an urgent issue that needs to be changed.