The quest for a potent treatment to combat cancer, which has emerged as the primary ailment afflicting mankind, has spurred the advancement of many approaches to investigate this affliction. Researchers and medical professionals have faced significant challenges in developing innovative treatments to overcome obstacles in cancer treatment and uncovering crucial insights into cancer development and progression. Comprehending the fundamental principles of the interaction between the human immune system and tumor cells has facilitated the development of novel and inventive approaches to cancer immunotherapy. The first progress witnessed in immunotherapy sparked enthusiasm among the scientific and clinical communities, since these approaches demonstrated significant potential for cancer treatment. However, there are other obstacles that currently hinder immunotherapy from being recognized as a truly effective treatment in the battle against malignant neoplasms. This review is trying to identify, assess, characterize, and define the main novel trends in immunotherapy and biotechnological therapies for cancer treatment.