Background: Nursing orientation programs are critical for integrating newly hired nurses into healthcare settings, enhancing their clinical competence, patient safety, and job satisfaction. Despite their importance, the effectiveness of these programs in improving nursing practice and patient outcomes is not always fully understood. This study evaluates the impact of Aster Sanad Hospital's nursing orientation program on newly hired nurses. Method: A cross-sectional survey was conducted with 164 newly hired nurses who completed the orientation program within the past six months (January 2024 to July 2024). The survey assessed nurses’ perceptions of the program’s impact on their clinical knowledge, confidence, patient safety, and ability to provide high-quality patient care. Data were analyzed using descriptive statistics. Results: The study found generally positive responses to the orientation program. Most participants (51.2%) strongly agreed they were well-informed about the program, and over half (53.7%) felt the program contributed to improved patient safety. Regarding knowledge acquisition, 51.2% of nurses strongly agreed that the program enhanced their clinical knowledge, and 95.8% felt it would help them provide better patient care. Confidence in delivering independent care was high, with 97.6% agreeing that the program increased their self-efficacy. Additionally, staff satisfaction (56.1%) and patient satisfaction (58.5%) with nursing care were positively influenced. However, 52.4% of nurses suggested that modifications to the program were necessary to better meet clinical and organizational needs. Conclusion: The findings suggest that the nursing orientation program at Aster Sanad Hospital has a positive impact on new nurses' clinical competencies, confidence, and patient safety outcomes. It also improves staff and patient satisfaction. However, ongoing program evaluation and adjustments are needed to address evolving healthcare demands and ensure continued effectiveness in preparing nurses for independent practice.