Medicinal plants have been integral to traditional medicine for millennia, serving as vital resources for treating a wide range of ailments. This review explores the importance of these plants, focusing on their antioxidant properties and the phytochemicals responsible for their therapeutic effects. Approximately 10% of vascular plants are recognized for their medicinal qualities, with natural antioxidants, particularly phenolic compounds and flavonoids, playing a crucial role in health maintenance by scavenging free radicals. The review delves into the molecular mechanisms underlying antioxidant activities, including both enzymatic and non-enzymatic defenses, emphasizing their significance in combating oxidative stress. Notably, members of the Lamiaceae family exhibit diverse species with potent antioxidant capabilities. Various in vitro models are evaluated to assess these antioxidant properties, highlighting the potential of medicinal plants as sustainable sources of natural antioxidants. The findings underscore the relevance of these plants in modern pharmacology and nutrition, advocating for further research to standardize extraction methods and identify specific active compounds. Ultimately, the continued exploration of medicinal plants can contribute significantly to public health and the development of innovative therapies rooted in nature, enhancing our understanding of their role in promoting health and preventing disease.