Premenstrual Syndrome (PMS) is a common condition among adolescent girls, characterized by various physical, emotional, and behavioural symptoms occurring before menstruation Despite its prevalence, awareness and understanding of PMS remain limited, particularly among adolescent girls A lack of knowledge can lead to misconceptions and inadequate management of the symptoms, and collect the 50 samples selected by using purposive sampling There was significant improvement in the knowledge of Adolescence girls following the administration of structured teaching program on Premenstrual Syndrome. The majority of respondent 90% had inadequate knowledge on Pre-menstrual syndrome.