Patient handoffs between the Operating Room (OR) and Post-Anesthesia Care Unit (PACU) are critical for ensuring continuity of care and patient safety. However, these transitions often occur under high-stress conditions and are prone to communication breakdowns, contributing to adverse events and medical errors. This review highlights the significance of standardized communication frameworks, such as SBAR (Situation, Background, Assessment, Recommendation), in mitigating these risks. Evidence suggests that structured handoffs improve information accuracy, reduce errors, and enhance patient outcomes. Despite these benefits, barriers such as human factors, systemic inefficiencies, and resistance to change persist. Recommendations include targeted training, technological integration, and fostering a handoff culture emphasizing clear communication. Future research should focus on long-term impacts of standardized frameworks and explore innovative solutions like AI for optimizing handoff processes.