Aim and background: This systematic review aimed to investigate the efficacy of photobiomodulation (PBM) on the acceleration of orthodontic tooth movement (OTM). Review methods: An extensive electronic search for randomized control trials via Medline (via PubMed), The Cochrane Controlled Clinical Trials Register, and Science Direct up to October 15, 2023 was done. Hand searching was performed for relevant journals. Reference articles were retrieved and exported to Zotero software. The risk of bias was assessed using Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2). Results: A total of 14 articles were considered for systematic review. Most of the studies arrived at the consensus that photobiomodulation (PBM) indeed accelerates the pace of tooth movement and significantly diminishes the time required for achieving proper tooth alignment. Conclusion: The synthesis of available evidence in our analysis reveals a substantial body of research suggesting a positive effect of PBM on accelerating tooth movement. However, the existing variations in PBM parameters, and outcome measurements emphasize the necessity for more standardized approaches in future investigations.