Scholars International Journal of Traditional and Complementary Medicine (SIJTCM)
Volume-7 | Issue-09 | 118-123
Original Research Article
PRCP- One Possible Novel Key Gene for the Entry of 2019-nCoV into Human Cells
Ms. Pujaa, B
Published : Oct. 8, 2024
Abstract
The ACE2 (Angiotensin I Converting Enzyme 2) receptor has been considered to be the major receptor of 2019-nCOV, the causative pathogen of the world wide prevailing COVID-19. Since, ACE2 is widely expressed across a variety of organs and moderately expressed in lungs, it raises a confusion about what makes the lung tissue the most infected in the Corona Virus Disease. Thus we hypothesized that there could be certain other genes playing key roles in the entry of 2019-nCOV into the human cells. Here, we found that PRCP (prolyl-carboxypeptidase) which is highly expressed in lungs than ACE2, has interactions with Bradykinin and has been proved as a potential target for obesity, could be a possible gene playing important role in the Corona Virus entry. In this study we have tried to dock the PCRP protein with two ligands [Epigallocatechin and Theaflavin] which could possibly reduce the effect of this protein.