Background: Dengue fever is a mosquito-borne viral disease that has emerged as a significant public health concern in Kolkata, with a substantial burden on the healthcare system. Also, this disease shows and additional impact on liver. Objective: To investigate the epidemiological trends of dengue fever in Kolkata and its effect on liver function. Methods: A retrospective study was conducted using data from [Ashok Laboratory] in Kolkata. Patients diagnosed with dengue fever between [July, 2023 to June, 2024] were included. Demographic, clinical, and laboratory data were analyzed. Results: A total of [6132] patients were included. The majority were [10-30] years old, and [males]. The incidence of dengue fever was highest during [monsoon season]. The data shows that SGPT/ALT and SGOT/AST value is very high on the dengue positive individuals and total bilirubin value is also high on dengue positive individuals. Conclusion: This study highlights the significant impact of dengue fever on liver function in Kolkata. The findings suggest that early detection and management of dengue-induced hepatic dysfunction are crucial to prevent severe complications. Public health measures should focus on vector control, timely diagnosis, and appropriate treatment to mitigate the burden of dengue fever in Kolkata.