Introduction: Uterine rupture is a solution of complete or incomplete non-surgical continuity of the wall of the gravid uterus. It is a dreaded obstetric disease with a poor maternal-fetal prognosis in terms of morbidity and mortality. Objective: To study the epidemio-clinical, therapeutic and prognostic aspects of uterine rupture at the Fousseyni Daou Hospital in Kayes. Materials and Methods: This was a cross-sectional, descriptive and analytical study with retrospective collection, from 1 January2012 to 31 December 20121. We included in our study all cases of uterine rupture diagnosed and treated at the Fousseyni Daou Hospital in Kayes during the study period. Results: The frequency of uterine rupture was 0.3%. The mean age of parturients was 29 years with extremes of 15 and 45 years. Parturients were evacuated in 78.74% of cases. Prolonged work was the leading reason for evacuation with a frequency of 14.2%. Uterine scarring was the top risk factor with 27.6%. Complete ruptures accounted for 81% and the breech was segmental in 69.8% of cases. Hysterorrhaphy was performed in 75.6% of parturients. The outcome was favourable in 59.52% of cases and anaemia was the most frequent postoperative complication with 34.1%. The maternal death rate was 7.9% and the fetal death rate was 74.6%. Conclusion: Uterine rupture is an obstetric-surgical emergency whoseprognosis depends on the speed of diagnosis andmanagement.