Abstract: This paper is related to study the potential of orange peel on the removal of copper ions from simulated wastewater using different design parameters by adsorption technique. The operating parameters studied to adsorb copper ions using orange peel as an adsorbent material were initial concentration of copper, absorbance material packing height which was orange peel, pH of copper feed inlet solution, and treatment time, these parameters were varied from (1-100) mg/l, (10-50) cm, (1-8), and (1-60) min respectively. All experiments were carried out at constant feed flow rate (1 l/min) and constant temperature 25°C. Results show that the higher removal efficiency was 89.25 % for copper from aquatic solution and this efficiency was decreased with increasing of initial concentration and pH while the removal efficiency increased with increasing adsorbent material bed height and contact time. The residues of orange peels that loaded with copper ions were prepared to use it as a rodenticide by applying it on the laboratory rats and calculate the half lethal dose (LD50). The residues show a good ability to use it as a rodenticide and the LD50 calculated was in the same range mentioned in the literature. By this way, it can possess different benefits in the same time, which are remove the toxic copper ions from contaminated the water by highly efficiency, get rid of agricultural waste orange peel and finally prepare an active, cheap and simple rodenticide. So, it can discard more toxic waste in a coast and eco-friendly method accessing to Zero Residue Level (ZRL) concept.