Introduction: Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing a severe form of COVID-19. And these Patients with a severe form of COVID-19 tend to have a high viral load. Objective: Identify biomarkers that show significant variation between different covid-19 viral load groups in T2DM patients in Pointe-Noire. Methods: We recruited a total of 206 participants for this study. Detailed information on age, gender, and health status of participants was collected from medical records. Biomarkers were quantified from blood samples and sars cov-2 virus was identified using the PCR technique on nasopharyngeal swabs. Viral load results were deduced from threshold cycles (CT) and subjects were grouped into two groups Ct < 25: Strong positive = High viral shedding and If Ct: 30 and 35 inclusive: Weak positive = Low viral shedding. Results: we found that fever (116/100%), Fatigue (115/99.1%), dyspnea (114/98.2%) and Cough (108/88.8%) were the most common signs in our population. study with high viral shedding. Non-survivors numbered 44 out of 46 for the same group. Biomarkers: CRP, ESR, CBC, GLY, HBA1c, DDI, Creat were significantly disrupted depending on viral load between non-survivors and survivors. Conclusion: This study showed that a high viral load was a source of disturbance of CRP, VS, CBC, GLY, HbA1c, DDI, Creat, signalling a poor prognosis.