Background: This systematic review aimed to evaluate the available clinical evidence on the plaque removal effectiveness of charcoal-infused toothbrushes in comparison to non-charcoal brushes. Methods: An online search was conducted in major scientific databases. Inclusion criteria were experimental clinical trials conducted on participants aged 18 years or older that evaluated the plaque removal effectiveness of charcoal-infused toothbrushes compared to non-charcoal brushes, with no limitations on the language or publication date. Results: Out of 147 studies, 2 met the inclusion criteria. The Risk of Bias in the included articles was determined as “high”. The findings were mixed regarding the plaque removal effectiveness. One of the studies showed higher efficacy for charcoal-infused toothbrushes. In contrast, the other study showed a similar effect for both types of brushes. The meta-analysis could not be performed due to the small number of eligible studies, with each utilizing different outcome measures. Conclusions: Within the context of this review, it is unclear whether charcoal-infused toothbrushes are better oral hygiene aids than non-charcoal brushes. Therefore, further research over a longer duration is needed to reach a conclusive statement. Healthcare professionals and the public should be cautious when recommending or utilizing such novel products that lack enough scientific support.