The business results of a commercial enterprise are a comparative relationship between the results achieved during business processes and the investment costs funded to achieve those results. Business results reflect input resource exploitation, utilization, and management to achieve each enterprise's business aims. In reality, different factors affect the business results of enterprises in general and Shopee Vietnam in particular, including microeconomic, macroeconomic, and industry environment factors. With a business analysis research approach, in this article, the authors investigate the factors affecting Shopee Vietnam's online business performance: Online product factors of Shopee; Economic, financial, and customer income factors; Online payment method factors of Shopee; Product pricing strategy factors of Shopee; Cultural and social factors; scientific, technological, and online shopping experience factors and Competitive factors in online business to develop a linear regression model to determine the extent of these factors impact on the online business result of Shopee Vietnam.