This study intends to describe the global knowledge of senior high school students at Cilegon City and Serang City. This study aimed to describe the level of global knowledge high school students at Cilegon and Serang City, and compare the level of global knowledge among high school students at Cilegon City with high school students at Serang City by using „t‟ test for large sample group. The authors performed the statistical analysis in order to find a comparison of global knowledge among senior high school students in the study site by using 't' test for large sample group. With 208 degrees of freedom, and at the trustworthiness level of 95%, it obtained the value of t table about 1.67. The t value of Comparison on Global Knowledge between senior high school student at Cilegon City and senior high school students at Serang City of 0.216 is smaller than t table value of 1.67. According to this condition, there is no significant difference between Global Knowledge of senior high school students at Cilegon City with senior high school students at Serang City. However, in a simple, based on the difference of the average score (mean) between the two groups of respondents, in fact it can be seen that there is the differentiation of Global Knowledge between senior high school students at Cilegon City with senior high school students at Serang City. Actually, the mean score of Y group (senior high school students at Serang City) is slightly larger than the mean score of X group (senior high school students at Cilegon City). The meaning of Global Knowledge of senior high school students at Serang City is slightly better than Global Knowledge of senior high school students at Cilegon City. Global Insight senior high school students in the city of Cilegon and Serang did not show a significant difference. This happens because of an environmental socio-cultural students in the two cities have in common as autonomous cities, with characteristic primary as a center of heavy industry and service business in the city of Cilegon, as well as industrial center services, central government activities city, county, and also the province of Banten.