Introduction: Orthodontic management of patients with cleft lip and palate is a tedious process requiring meticulous treatment planning. However, in patients with a fairly good facial profile, non-surgical management using orthodontic treatment alone can produce astounding results in correction of malocclusion and to achieve a pleasing smile. A properly executed orthodontic treatment enhances not only the smile, but also the masticatory efficiency, speech and overall quality of life of the patients with cleft lip and palate. Methods: This case series describes orthodontic management of three patients with cleft lip and palate who have been treated by distinct treatment modalities. Results: An outline of the different orthodontic treatments along with possible interdisciplinary management has been explained in this case series. Conclusion: We therefore understand that in patients with cleft lip and palate who have a reasonably good facial profile, complete orthodontic therapy with individualized treatment plan is vital to provide good physiological, functional and aesthetic outcomes.