Background: Dengue virus infection (DI) is an important health problem in many Southeast Asian countries. In recent years, several epidemics of DI have been reported from India. Liver involvement is known to occur in children with DI. The degree of liver dysfunction in children with DI varies from mild injury with elevation of transaminase activity to severe injury with jaundice; a few patients have presented with a clinical illness resembling liver failure. The severity of liver dysfunction varies according to the type of clinical presentation of DI, and is more common in patients with complicated dengue. Materials and methods: This is a prospective, cross-sectional, hospital-based study was carried out in the Department of Pathology at Tertiary Care Teaching Hospital over a period of 1 year. Clinical examinations were performed by a physician on each study participant. Demographic variables, as it has been published in previous work, and clinical profiles of study participants were collected by nurses using the structured questionnaire. The diagnosis of dengue was made based on positive enzyme-linked immunosorbent assay result for specific IgM antibody for dengue in serum. Result: When compared to dengue-negative cases, dengue-positive cases had thrombocytopenia, leucopenia, erythrocytosis, high hemoconcentration, low mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). However, binary logistic regression predicted platelet count, total leucocytecount, MCH, MCHC, neutrophil count and lymphocytecountas significant predictors of dengue positivity. Conclusion: In conclusion, liver injury is nearly universal in adult patients with DI. Though liver involvement is asymptomatic in a large majority, in some patients it leads to clinical manifestations of liver disease and may occasionally lead to acute liver failure and death. Care must be taken to not make a mistaken diagnosis of viral hepatitis. Further studies are needed to define the mechanisms of liver injury due to this infection.