Introduction: Menstrual regulation, or the evacuation of the uterus of a woman at risk of being pregnant is done to ensure a state of no pregnancy, was introduced in Bangladesh in the 1970s in the context of a restrictive abortion law, in part to reduce maternal morbidity and mortality associated with unsafe abortion. Objectives: The study is designed to see the efficacy, safety and acceptability of uterine evacuation by medication using oral mifepristone and buccal misoprostol. Methods: All the patients attending the outpatient department. Of obstetrics & gynaecology in DNMCH during the study period seeking for MRM unwanted pregnancy. Of them 100 cases were selected purposively according to inclusion and exclusion criteria. Success was defined as medical abortion. Results: The oral misoprostol-mifepristone regimen, used by 100 women with a gestational age below 63 days, had a success rate of 92.0%. Ninety two percent patients were completely evacuated and Eight percent patients were incompletely evacuated. Conclusion: An evidence based regimen of 200 mg of mefipristone orally followed by home use of 800 mcg of buccal misoprostol 24hr later is safe and effective up to 9 weeks (63 days) of pregnancy. Further the need of aspiration for any reason was low and hospitalization was rare.