The study was done to investigate the knowledge and practice of occupational health hazard among two hundred and thirty two (232) healthcare workers in Kogi State Specialist Hospital (KSSH). The healthcare workers were selected through a multistage sampling technique, and the instrument used was self-administered semi-structured, closed ended questionnaire that assessed the health workers knowledge and practice of occupational health hazard as well as the relationship and factors that influences practice of occupational health hazard. Result from the findings of the study showed that 67.7% majority of the healthcare workers had good knowledge on occupational health hazard, and 92.2% majority of the healthcare workers had good practice towards occupational health hazard. More findings from the study showed that there is a significant relationship between the healthcare workers gender (Sig. values = 0.045 < 0.05), and knowledge (Sig. values = 0.007 < 0.05) on the practice of occupational health hazard. Finally from the study, female healthcare workers [AOR = 1.932; CI = 1.456 – 2.562], those within 30 – 39 years [AOR = 1.482; CI = 2.708 – 7.150], married [AOR = 14.308; CI = 8.154 – 25.105], Christians [AOR = 1.111; CI = 2.227 – 4.143], hospital attendants [AOR = 4.450; CI = 2.740 – 7.228], and healthcare workers with good knowledge [AOR = 2.334; CI = 1.749 – 3.141] are significant likely to practice good occupational health hazard prevention compared to their counterparts.