Background: In recent years, there has been a growing interest in exploring innovative approaches to healthcare delivery that prioritize patient-centred care and enhance clinical outcomes. Nurse-led rounds have emerged as a promising strategy to foster patient engagement, improve communication among healthcare team members, and optimize patient care delivery. Therefore, the objective of the present study was to examine the impact of Nurse-Led Rounds on patient satisfaction and patient clinical outcomes in a Middle Eastern Country. Methods: A mixed-method research design was used in this study. A Clinical trial was carried out by using a non-equivalent control group design was adopted to design to assess the impact of Nurse-led Rounds on patient satisfaction and patient clinical outcomes through quantitative data collection and semi-structured individual interviews identified the benefits of hourly rounding to enhance patient satisfaction through qualitative data collection. The study was conducted at New Najran General Hospital, Najran Saudi Arabia. The quantitative data was collected from 68 clients and qualitative data with 10 participants. Results: The results of the quantitative analysis showed that the experimental group's mean score significantly improved when nurse-led rounds were implemented, reflecting the quality of care given by nurses. Compared to the control group, which had a mean score of 4.75 (SD=1.578) on the first day of hospitalization, the experimental group had a higher mean score of 6.06 (SD=0.531). This early disparity implies that the experimental group had a higher standard of care from the beginning. The qualitative study revealed two primary themes about individual advantages and organizational benefits were found, according to the qualitative study. The deployment of Nurse-led rounds was judged by clients to offer many specific benefits related to patient satisfaction and overall clinical result levels. Theme 1: Better communication, reduced anxiety, support for drug administration and patient safety, and general increases in patient satisfaction. The second theme focuses on improving overall client healthcare outcomes, improving interprofessional collaboration and teamwork, and reducing readmission rates. Conclusion: The implementation of nurse-led rounds has demonstrated a significant positive impact on both patient satisfaction and clinical outcomes. Through the integration of nursing expertise, patient-centred care principles, and effective communication strategies, nurse-led rounds have enhanced the overall patient experience and contributed to improved clinical outcomes.