Scholars International Journal of Obstetrics and Gynecology (SIJOG)
Sch Int J Obstet Gynec
Professor ADEL TAHA HASAN ABU-HEIJA
Scholars Middle East Publisher
Country of Origin:
“Scholars International Journal of Obstetrics and Gynecology” ISSN 2616-8235 (Print) & ISSN: 2617-3492 (Online) is a Bi-Monthly, peer reviewed, open access, Journal published by published by “Scholars Middle East Publishers”, Dubai, UAE. This Journal publishes Original Research Articles, Review Article, Mini-Reviews, Short Communications, Case Reports and Case Series within the whole field of Obstetrics and Gynecology under Medical Sciences.
Scope of Journal
The scopes of “Scholars International Journal of Obstetrics and Gynecology” includes all the areas of research activities in all fields of Obstetrics and Gynecology such as- Maternal-fetal medicine, Reproductive endocrinology, infertility, Female pelvic medicine and reconstructive surgery, Family planning, Pediatric and adolescent gynecology, Menopausal and geriatric gynecology, Neonatal infection, in-vitro fertilization (IVF), gynecologic oncology etc
Professor ADEL TAHA HASAN ABU-HEIJA, FRCOG
Dept. of Obstetrics and Gynecology, College of Medicine, Mutah University, Al-Karak, JORDAN
Professor Surekha Tayade
Professor , Obstetrics and Gynecology , Mahatma Gandhi Institute of Medical Sciences, Sevagram Wardha, Maharashtra, India
The Relationship between Vascular Endothelial Growth Factor A (VEGFA) Gene Polymorphism and Pre-Eclampsia in Egyptian Pregnant Women
Sobhy Hassab El-Nabi, Islam El-Garawani, Ayman Elsayed, Heba Salama
Page Numbers : 157-162
DOI : 10.36348/sijog.2020.v03i06.004
Pre-eclampsia (PE) is a complicated heterogeneous disorder associated with an increased risk of maternal death. There is a major variation in the literature about the genetics of pre-eclampsia (PE). This study aims to estimate the association between Vascular Endothelial Growth Factor A (VEGFA) gene single nucleotide polymorphism (rs1570360) and the development of PE in the Egyptian population. Genotyping was performed using the tetra-primer amplification-refractory mutation system (ARMS-PCR) and the results were confirmed by the PCR-RFLP method in 100 patients with PE and 100 PE-free patients. Results revealed that GG (wild type) genotype of rs1570360 was identified in 100 patients, (42%) of them had pre-eclampsia. SNP genotype AA was found in 84 patients and (42%) of them had pre-eclampsia. The frequency of AG genotypes was significantly low (16 %). However, the odds ratio was 40.37 for homozygocity and 9.5 for heterozygous alleles. Our study concluded that the AA and AG genotypes were not associated with PE. There is a significant relationship between the AA allele polymorphism and the severity of PE.
Original Research Article
June 28, 2020
Comparison of Hemoglobin and Hematocrit Concentration between Rh- Hydropic, Non-Hydropic and Control Group; Severe Vs Mild Hydropic Group
Introduction: Maternal RBC alloimmunization results from exposure and response to a foreign RBC antigen. Transplacental fetal to maternal hemorrhage is the most common cause of alloimmunization. Rh incompatibility can lead to either fetuses with hydropic features or non hydropic. The precise mechanism leading to the development of hydrops is not certain. All direct fetal sequelae of hemolytic disease relate to the development of anemia. In general, the fetus tolerates mild to moderate anemia well. However, metabolic complications develop as the anemia worsens. Because the RBC is the principal fetal buffer, a metabolic acidemia with hyperlactatemia develops in fetuses with severe anemia. Objective: To compare the difference in mean hemoglobin and hematocrit concentration between Rh-hydropic, non hydropic and control group and further based on severity of hydrops. Methods: A Total of 40 pregnant patients were enrolled which included 10 hydropic fetuses of Rh isoimmunised mothers, 10 non hydropic fetuses of Rh isoimmunized mothers. Control group included 18 Rh positive women without any fetal complication and 2 fetuses in women undergoing cordocentesis. Blood sampling was done at time of intrauterine transfusion and sent for estimation of hemoglobin and hematocrit in fetal blood. Pregnancies were followed up till delivery and fetal outcome noted. Result: Mean values of haemoglobin in hydrops group are 4.54g %, as compared to 6.65g % and 14.26 g % in non-hydrops and control group. Mean haematocrit in hydropic group is 13.91% as compared to 20.25% and 43.51% in non hydropic and control group. The mean haemoglobin concentration in mild hydrops was 5.17g % as compared to 2.7g % in severe hydrops. Conclusion: There was severe hemoglobin and hematocrit deficit in hydropic fetuses as compared to non hydropic and normal fetuses matched for the gestation age. Thus severity of anemia can be considered a strong marker for development of hydrops in Rh isoimmunized fetuses.
Original Research Article
June 26, 2020
A Study of Perinatal Outcome in Women with Preterm Labour at a Tertiary Care Hospital
Dr. Kavita Chaudhary, Dr. Nupur Hooja, Dr. Premlata Mital, Dr. Urmila Kumari, Dr. Saloni Sethi, Dr. Ankita Chaudhary
Page Numbers : 147-152
DOI : 10.36348/sijog.2020.v03i06.002
Introduction: Preterm labor is the leading cause of neonatal morbidity all over the world. Over the past two decades despite major preventive efforts, the incidence of preterm birth has remained constant at about 5-10% of live births. The etiology is often multifactorial and poorly understood. Neonatal complications which arise from preterm births are birth asphyxia, respiratory distress, low birth weight, infective neonatal hypoglycemia and neonatal death. With this background the present study was done to find out perinatal outcome in women presenting with preterm labour. Material and methods: The present study was a descriptive study conducted in the Department of Obstetrics and Gynaecology. 100 consecutive women presented with preterm labour between 28 to <37 weeks were included in the study after obtaining written informed consent. Mode of delivery and neonatal outcome were noted. Data were compiled and analyzed. Results: Majority of the women were between 20 to 35 years of age, Hindu, Literate, belonging to rural area, low socio-economic status, and had normal BMI. 60% women were primigravida. 65% women had gestational age ≥34 weeks. Mean weight of the babies in our study was 1.7 ± 0.4 Kg and mean APGAR score at 5 min was 7.02 ±1.03. 46% babies were admitted in NICU for various reasons and 12% babies had perinatal death. Most common reason for NICU admission was birth asphyxia (42%) followed by extreme prematurity (16%), septicemia (12%) and jaundice (11%). Conclusion: Appropriate and innovative preventive intervention, customized individuals need may prevent preterm births and improve neonatal outcomes.
Original Research Article
June 21, 2020
Demographic Characteristics of Low Birth Weight Newborn Admitted in Rajshahi Medical College Hospital, Rajshahi, Bangladesh
Rahnuma Shirin, Ahmed Masiha Jamil, Asgar Hossain, Mst. Tanjila Momtaz
Page Numbers : 142-146
DOI : 10.36348/sijog.2020.v03i06.001
Introduction: Neonatal hypoglycemia is a common metabolic problem which often goes unnoticed due to lack of specific symptoms. It is a common abnormality in low birth weight neonates. It is associated with neurological damage and death when it occurs in the first few days of life. Objective: To assess the demographic characteristics of low birth weight Newborn Admitted in Rajshahi Medical College Hospital, Rajshahi, Bangladesh. Methods: This descriptive, cross sectional hospital based study was aimed to describe the prevalence of hypoglycemia in low birth weight newborn admitted in Rajshahi medical college hospital in 1st 72 hours of life. A total of 264 neonates were enrolled in the study during the period of July 2015 to June 2017. Written informed consent was obtained. Clinical assessment and 72 hours blood glucose were recorded. Serial determination of blood glucose were recorded using glucometer at 1,2,6,12, 18, 24, 36, 48, 60 and 72 hours of age. Any abnormal result was immediately confirmed by the laboratory. Results: In our study we found 9.5% (n=25) Low Birth Weight newborn had hypoglycemia. The occurrence of hypoglycemia was within 1st 0-24 hours in 60% cases (n=15), >24-48 hours in 32% cases (n=8) and >48-72 hours in 8% cases (n=2). In this study male female ratio was 1.1:1. Mean±SD birth weight was 1681.82±301.69 grams and mean gestational age was 31.70±3.60 weeks. In this study majority of mother were <20 years of age and primiparous. Mean±SD maternal age was 19.86±5.960 years and mean± SD maternal weight was 48.23±3.592 kg. There was no significant relationship between increased incidence of hypoglycemia and sex, birth weight, gestational age of the baby and maternal age, maternal weight and parity of the mother. Conclusion: So low birth weight newborn should be kept under close observation and periodic monitoring of blood glucose should be done to avoid risk of hypoglycemia.
May 16, 2020
Cervical Cancer - Palliative Embolization Due to Bleeding A Case Report
Yasser M Noorelahi, Nura J Alsaddah, Arya Bagherpour
Page Numbers : 138-141
DOI : 10.36348/sijog.2020.v03i05.001
Advanced cervical cancer results in infiltration of adjacent organ structures and can be complicated by severe bleeding. Endovascular embolization is a life-saving therapeutic option. This case highlights a unique presentation of a severely bleeding recurrent cervical cancer infiltrating the rectum in a patient with prior hysterectomy. Arterial supply to the tumor was almost exclusively supplied by the superior rectal artery originating from the inferior mesenteric artery. She was successfully treated with selective endovascular embolization using 500 micron particles. The patient had immediate resolution of severe bleeding, no procedural-related complications, and reduced recurrence of bleeding on long-term follow-up.
Original Research Article
April 30, 2020
A Comparative Study of Oxidative Stress in Preeclampsia and Normal Pregnancy
Constance E Shehu, Bissallah A Ekele, Bilbis L Suleman, Abubakar A Panti, Ukwu A Eze, Ahmed T Burodo, Bilal Suleiman
Page Numbers : 127-133
DOI : 10.36348/sijog.2020.v03i04.004
Objectives: Pre-eclampsia is a human pregnancy-specific disorder. It is an important cause of maternal mortality in Sokoto, Northwestern Nigeria and is associated with a five-fold increase in perinatal mortality. Identifying modifiable factors to decrease oxidative stress in the pregnant woman’s environment may be an inexpensive and non-invasive therapy for decreasing the maternal and foetal morbidity and mortality associated with preeclampsia. This study aimed at comparing the levels of 3 oxidative stress markers; glutathione peroxidase (GPX), superoxide dismutase (SOD), and malondialdehyde (MDA) and 4 antioxidants (Catalase, Vitamins A, C and E) in normotensive and preeclamptic pregnant women in Sokoto. Methodology: This was a prospective cross-sectional study of 199 normotensive and 201 preeclamptic women attending the antenatal clinics or admitted to the pre-eclamptic/eclamptic wards of Usmanu Danfodiyo University Teaching Hospital, Sokoto or Specialist Hospital Sokoto. Structured questionnaires were administered and relevant information obtained. Blood samples were obtained by standard laboratory techniques and assayed for the oxidative stress markers and antioxidants. Statistical analysis was by GraphPad InStat Software (version 3.0) San Diego, USA. Results: The mean levels of oxidative stress markers MDA and GPX were increased in the preeclamptic women (3.44±1.25 and 71.53 ± 26.02) when compared to controls (3.024±1.08 and 62.58 ± 22.45) respectively (p=0.00) while SOD was decreased in the cases (13.00±15.27) when compared to the controls (57.21 ± 38.08) p=0.00. The antioxidant Vitamins A and C were significantly decreased in the preeclamptic women (1.52±1.68 and 0.14±1.33) p=0.00 while Catalase was increased (50.93±36.22; p=0.00). Conclusion: The results of this study are in agreement with most previous studies which showed that markers of lipid peroxidation were increased in the plasma of women with preeclampsia. Follow-up studies, are needed to enable us arrive at the certain conclusion that interventions with antioxidants and vitamins may be the panacea to this disease in our sub-region.
April 30, 2020
Malignant Mixed Ovarian Germcell Tumour with Clear Cell Carcinoma in A Post Menopausal Women
Dr. Rejla R, Dr. Deepa S, Dr. S. Sankar
Page Numbers : 134-137
DOI : 10.36348/sijog.2020.v03i04.005
Malignant ovarian germ cell tumours are uncommon and it occurs mainly in adolescent age group1, and very rarely in post-menopausal period. Clear cell carcinoma ovary occurs in older age groups . They occur either in pure form or maybe associated with other types of germ cell neoplasm. Yolk sac tumours rarely coexists with epithelial carcinoma, and is rare in post- menopausal women. Here we report a case of 60-year-old post-menopausal women with bilateral ovarian malignancy which contained components of clear cell carcinoma and yolk sac tumour. Such a combination of tumours are rare .