Scholars International Journal of Biochemistry (SIJB)
Sch Int J Biochem
Dr. Saber Mohamed Abd-Allah
Scholars Middle East Publisher
Country of Origin:
“Scholars International Journal of Biochemistry” ISSN 2616-8650 (Print) & & ISSN: 2617-3476 (Online) is a Bi-Monthly, peer reviewed, open access, Journal published by published by “Scholars Middle East Publishers”, Dubai, UAE. This Journal publishes Original Research Articles, Review Articles, Mini-Reviews, Short Communications, Case Reports and Case Series, Essays within the whole of Biochemistry.
Scope of Journal
The scopes of “Scholars International Journal of Biochemistry” includes all the areas of research activities and findings in all fields of Biochemistry like Animal biochemistry, Bioluminescence, Bio-organic Chemistry, Biotechnology, Cell biology, Chemical ecology, Chemotaxonomy, Clinical biochemistry, Endocrinology, Endocrinology, Enzymatic chemistry, Enzymology, Genetic engineering, Hematology, Immunology, Metabolic Biochemistry, Molecular biology, Molecular chemistry, Molecular genetics, Neurochemistry, Nutritional Biochemistry, Pharmaceuticals, Photosynthesis, Structural biochemistry, Toxicology, Virology, Xenobiotics, etc.
Dr. Saber Mohamed Abd-Allah
Scientist, Shanghai Institute of Biochemistry and Cell Biology, China
Dr. A.P. Attanayake
Dr. A.P. Attanayake, Senior Lecturer in Biochemistry, University of Ruhuna, Sri Lanka
Prof. Rizwan Ahmad
College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, KSA
Dr. Dharmveer Yadav
Assistant Professor, Department Of Biochemistry, S.M.S Medical College, Jaipur Rajasthan, India
Assist Prof. Dr. Ammar Abdul Razzak Mahmood
Dept. of Pharmaceutical Chemistry-College of Pharmacy-University of Baghdad/Baghdad-IRAQ
Hema Krishna R
Dept. Environmental chemistry , University of Toronto, Canada
Dr. Sabyasachi Chatterjee
Senior research fellow (SRF), Biophysical Chemistry Laboratory, Organic and Medicinal Chemistry Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India
Dr. Nitin Sharma
Associate Professor, Dept. Of Biochemistry, Dr. Sampurnanand Medical College, Jodhpur (342001), Rajasthan, India
Dr. Khawajashakeel Ahmed
Head Dept. Of Biomedical Sciences Asmara College Of Health Sciences Asmara, Sate of Eritrea, Ethiopia
Study on Frequency of ABO Blood Grouping and Rhesus Phenotype Distribution in Tamil Nadu and Pondicherry of South India
R. Srikumar, R.Vijayakumar, E. Prabhakar Reddy, S. Ravichandran C, Naveen Kumar
Page Numbers : 199-200
DOI : 10.36348/sijb.2020.v03i09.002
Blood is a fluid which we have in our bodies that carries oxygen from the lungs to the rest of the body and also waste to be eliminated from the body. ABO and Rh blood group system is the most important system in transfusion and organ transplants. Though, many studies have been conducted in various parts of India to determine the local ABO and Rh distribution, no Indian study has so far been conducted to explore the South Indian especially Tamil Nadu and Pondicherry ABO and Rh distribution. The present study made an attempt to provide data on ABO and Rh blood group distribution across Tamil Nadu and Pondicherry. A total of 25,000 subjects of college students were included in this study and ABO and Rh (D) grouping was performed on all these samples. Data on the frequency of ABO and Rh(D) blood groups was expressed in simple numbers and percentages. The present study explored Among the ABO grouping system the highest frequency of blood group was found to be group O [10023(40.09%)], followed by group B [7447(29.79%)], and group A[6393(25.57%)]. The least common blood group was AB group [1137(4.55%)]. 94.69% Rh antigen was detected and the prevalence of Rh – ve was 5.13%. Of the 25000 individuals, the most common blood group was O followed by B and A and the least blood group was AB. The present study provides information about the relative distribution of various ABO blood grouping in the Tamil nadu and Pondicherry. This vital information may be helpful in planning for future health care blood transfusion services.
Original Research Article
Sept. 19, 2020
Sugarcane Burning - A Potential Cause of Disease in Affected Individuals of Households in Uitvlugt and Ogle, Guyana
Morisa Gamell, Aminuddin Mohammad, Kalyan Kumar Kakarla, Abdullah Ansari
Page Numbers : 193-198
DOI : 10.36348/sijb.2020.v03i09.001
The sugar industry is one of the earliest and most successful users of biomass for commercial energy production. Sugar cane harvesting by burning is an environmental health issue due to respiratory effects of smoke. The present study is to investigate the current situation concerning sugarcane burning as a potential cause of disease in affected individuals of households in Uitvlugt and Ogle, Guyana. A total of 50 households investigated at each study site, results showed that there were no chronically exposed households to sugarcane smoke and soot for the study site used as the control when compared to the study site at Ogle and Uitvlugt. Out of 50 a total of fifteen households investigated at parfait harmony which reported the presence of respiratory disease within their households; asthma and bronchitis was the most commonly reported. Ogle showed the least number of nine, and Uitvlugt showed the highest number of twenty three, both with asthma being the most common. Uitvlugt showed a complete total of fifty households reporting dermatological problems, they all complained of unbearable itching when exposed to the sugarcane soot. Ogle reported one incidence of this, and Recht door zee (control site) reported nil. In the case of cardiovascular problems, Uitvlugt showed the highest incidence of thirty seven, and both Ogle and Recht door zee (control site) showed five. Cancer was reported by nine households in Uitvlugt, two in Recht door zee (control site), and nil in Ogle. To conclude, there is a high prevalence of chronic exposure to sugarcane smoke and soot in Uitvlugt, and negligible prevalence of chronic exposure to sugarcane smoke and soot in Ogle. There is a high prevalence of these diseases in Uitvlugt, followed substantially less by Recht door zee (control site), and Ogle having a very small prevalence.
Original Research Article
Aug. 29, 2020
Anti Obesogenic Potential of Caralluma acutangula Bioactive Fractions
Dramane Paré, Jotham Yhi-Pênê N’do, Adama Hilou, Nogma Ernest Sombie, Mabozou Kpemissi, Sévastre Bogdan
Page Numbers : 183-192
DOI : 10.36348/sijb.2020.v03i08.004
Obesity is a chronic condition characterized by excess body fat which results in an increase in the body weight of patients. C acutangula is a medicinal plant used in traditional medicine in Burkina Faso for the management of weight gain. The objective of this study was to determine the anti obesity potential of the bioactive fractions of C. acutangula extract. The ethanolic extract of C. acutangula was fractionated to obtain the hexanic, dichloromethane, ethyl acetate, butanol and aqueous fractions. The effect of these fractions on weight gain, food intake and lipid biochemical parameters were determined in vivo. The inhibitory activity of digestive enzymes (pancreatic lipase, trypsin) and the antioxidant potential were evaluated for these fractions. The butanolic fraction showed the best activity with an inhibition of 68.20 ± 3.4% at 100 μg / ml. The ethyl acetate fraction gave the best activity on reducing body weight with 18.11% reduction to 50mg / kg of body weight against the control (hyperlipid diet) which gave increases in weight of 34.83% respectively. The ethyl acetate fraction at 25 and 75 mg / kg of body weight and the butanolic fraction at 50 mg / kg showed the best reductions in the triglyceride level with respectively 111.89 ± 28.6; 108.35 ± 10.5 and 108.9 ± 10.21 mg / dl against the control which gave a rate of 280 ± 8.43 mg / dl. Best activities on cholesterol levels, HDLc and LDLc have been observed. For the antioxidant effect, the fractions caused a reduction in the level of MDA and an induction of the production of catalase. These results demonstrate that the ethyl acetate and butanolic fractions contain antiobesity molecules and could therefore be used in the implementation of a phytomedicine.
Original Research Article
Aug. 14, 2020
Physiological Growth of Sunflower with Treatment of Zinc
Muhammad Imran Anwar, Saba Batool, Abdul Wadood Nadeem, Hajra Tabbasam, Sadia Batool, Shehnaz kousar
Page Numbers : 177-182
DOI : 10.36348/sijb.2020.v03i08.003
Metal ion contamination in the environment causes hazardous effects on plant growth, yield production, and also led to physical and chemical changes. Sunflower(Helianthus annus L.) plant is added to be one of the most edible seed crop growing in harsh climatic regions.it also have good water use efficiency. The study remains unclear about the physiological growth of sunflower with treatment of Zinc. A pot experiment was conducted in the old Botanical Garden at University of Agriculture, Faisalabad to analyze and check the impact of heavy metal zinc sulphat stress on sunflower (Heliantuus annuus) two hybrids FH687 and FH674. After three weeks varying concentration of zinc sulphate (0mM, 20mM and 40mM) along with 250ml tap water was applied in rooting medium. Every day 250ml water were applied to each pots .The crop was harvested after 45 days and morphological parameters were studied such as root length, shoot length, root weight, shoot weight and number of leaves. Zn stress significantly reduced the growth attributes. A marked drop in all morphophysiological attributes such as root length, leaf number and shoot length was recorded. Maximum reduction of growth, biochemical and physiological parameters was noted at 40mM concentration of zinc. Zinc toxicity involve in inhibition of cytoplasmic enzymes and damage to cell structures due to oxidative stress.it alter the catalytic function of enzymes which damage the cellular membranes and inhibit root growth. Zinc stress cause maximum effect on hybrid FH674 as compared to other hybrid FH687.
Original Research Article
Aug. 9, 2020
Clinical Biochemistry Laboratory Workload Trends 2007-2016 Including Liver Function Test in a Tertiary Care Centre
Dr. Meera.S, Dr. Rangaswamy R
Page Numbers : 167-170
DOI : 10.36348/sijb.2020.v03i08.001
Introduction: Laboratory tests are important for the confirmation of the diagnosis of the disorders and also they are required to see the prognosis or to monitor the effects of the treatment of diseases. Many laboratory tests are ordered inappropriately, some of the ordered tests reports have not been utilized neither for the diagnosis nor for the assessing the prognosis of the disorders. Methodology: Source of data was obtained by documentation maintained in the inpatient registers for routine and emergency tests. Study type and design is Descriptive Cross Sectional study. Results: The percentage of total number of investigations increased was calculated from the year 2007 to till 2016. In our study we found that there was more than 1000% increase in the laboratory workload over a period of 10years both for elective and emergency (around 742%) sample analysis. Discussion: There is an increase in the workload of both routine and emergency tests which were done in Central Biochemistry laboratory and found out the normal value reports in some samples, which were required neither for the diagnosis nor for the prognostic purpose of the disorders. Conclusion: The study revealed gross overuse of laboratory; the ordered tests were required neither for the diagnosis nor to see the prognosis or to monitor the treatment of the disorders. This inturn affect the patients and organization in terms of direct cost & indirect cost. Inappropriate tests may increase the laboratory overload which affects laboratory results adversely in terms of the quality and availability of the laboratory resources.
Aug. 9, 2020
A Review on Identification of Novel Biomarkers to Identify Genes in Breast Cancer
Breast cancer is the most common occurring cancer among women worldwide. Risk factors included drinking lot of alcohol, lack of physical exercise, family history, ionizing radiations and hormones replacement therapy during menupuase. BRAC1 gene play important role in biochemical processes occurring in cells of the breast cancer. It is highly abundant in tumor cells as compared to the normal cells of human body. It makes it strong and ideal candidate for biochemical and functional characterization at molecular level. The molecular pathways associated with tumor formation and progression of breast cancer not completely discovered yet. There is need to design such potential target or drugs that can target the cells of breast cancer and regulate the epithelial mesenchymal transition as well as reduces the number of cases due to breast cancer. Information regarding genes involved molecular pathways remains unclear. There is need to identify genes involved inthe development of breast cancer as well as prognosis. GEO database of NCBI especially used for breast cancer datasets searching.Cytohubba is used to identify the DEGs. Functional enrichment software that is used for classification and characterization of genes at functional level. Biological database such as STRING that designed for to construct PPI networks of DEGs. MCODE in Cytoscape-Intergerated plug in experimentally applied to check the interactions in PPI network. Cytohubba also used to check out the either hub genes functional or target newly drug for the breast cancer treatment. Kaplan–Meier is biological software that is used to check out the survival of individual hub genes subjected to breast cancer. X2K (Expression2Kinases) used to check out the expression of hub genes. The between hub gene and drug especially be designed in database of drug bank.
July 14, 2020
Treatment Method of Water based on the Magnetic Devices
Nguyen Le Thai, Dang Van Hai, and Trinh Tien Tho
Page Numbers : 163-166
DOI : 10.36348/sijb.2020.v03i07.003
Magneto - Electric Machine, a device based on the principle of electromagnetic radiation in water is used to separate the bonds of compounds in water. Since magnetic treatment has a variety of selective influences on different substances and processes, its application has wide potentials in the practice. This paper presents a research result on the influence of the magnetic field on the water's Total Dissolved Solids (TDS) and Potential of Hydrogen (PH). Then, the experimental results are conducted to show that the fluctuation of the magnetic field affects the concentration of PH and TDS in water.