Haya: The Saudi Journal of Life Sciences (SJLS) | Volume-2;-Issue-04
Original Research Article
July 30, 2017
Effect of Phoenix dactylifera fruit wine produced by Saccharomyces cerevisae on the haematological and some biochemical parameters in albino rats
Victoria O. Nwaneri-Chidozie, Salemcity, A. James, Sunday. Awe, Sandra Chioma Eke
Page Numbers : 116-121
DOI : 10.21276/haya
The effect of date palm fruit wine on the haematological and some biochemical parameters (lipid profile, lipid
peroxidation and protein) was investigated Date fruit wine was produced by fermenting the fruit must with
Saccharomyces cerevisiae from Guangxi Danbaoli, China aerobically for 6 days and anaerobically for four weeks at 28
OC. During both fermentation processes alcohol content, total yeast counts and total heterotrophic counts were
monitored. A total of 30 albino rats were divided into six (6) groups of 5 animals each. Group 1 (control) received the
normal rat feed and water; while groups 2 – 5 were administered date fruit wine at 0.3ml/kg, 0.6ml/kg, 0.9ml/kg and
1.5ml/kg body weight respectively and group 6 (standard) received white wine (carlorossi) 1.5mg/kg body weight for a
period of 28days.During the aerobic fermentation. Alcohol content increased from 0 to 5.5%, total yeast counts increased
from 4.69×102 to 15.39×102 cells/ml while total heterotrophic bacterial count ranged from 2.0 to 9.0 cfu/ml.
Lactobacillus casei and Lactobacillus spp. were encountered. During anaerobic fermentation .Yeast population dropped
from 8.90×102 cells/ml to 0.92×102 cells/ml. The final percentage alcohol was 9.2%. The result after the experiment
showed a general decrease in body weight across the groups compared to the control. Haematological indices showed no
significant difference (p<0.05) in PVC, RBC, WBC and Hb of the groups treated with Phoenix dactylifera (PD)
compared to the control. There was also a significant decrease (p<0.05) in lipid peroxidation in the liver homogenate
across the groups and also in the serum of the PD treated animals relative to the standard control. There was no
significant difference (p<0.05) in total cholesterol, LDL-C but elevated HDL-C in the PD administered groups compared
to the control. Triglyceride was significantly reduced (p<0.05) in the PD treated groups compared to the standard control.
The results of the present study showed that date fruit wine has no harmful effect on the blood tissue and vital organs
such as liver etc. Thus, if properly processed and refined, it could be a good source of commercial fruit wine, with
immense nutritional and health benefits.
Aug. 30, 2017
Revitalizing Phage Therapy in Combating Multi-Drug Resistant Bacteria
Aida Baharuddin, Amad Abdelkarim El Marghani, Idris Adewale Ahmed, Mohammed Razip Samian
Page Numbers : 122-130
DOI : 10.21276/haya
Bacterial infections are one of the most dangerous infections that threaten the existence and continuity of life.
Despite the discovery and manufacturing of effective antibiotics to tackle these menaces, bacteria have developed
resistance against such treatments and transformed into new mutant resistant strains. Bacteriophages, or phages, are
regarded as effective alternative antibacterial agents. Recently, scientists have been taking a closer look at the variety of
different phages that attack bacteria. This review primarily focuses on the potential of phage therapy as an alternative
treatment to overcome a wide spectrum of resistant bacterial infections, as well as current phage therapy advancement. It
also proposes the idea of engineering “broad-spectrum phage” to overcome a wide range of resistant bacterial infections,
and its advantages over antibiotics, individual phage, and phage cocktails.