Colonic obstruction due to sigmoid colon volvulus during pregnancy is a rare but complication with significant maternal and fetal mortality. That requires prompt surgical intervention (decompression) to avoid intestinal ischemia and perforation. We report the case of a 38-week pregnant woman with abdominal pain and subsequent development of constipation. Preoperative diagnosis was achieved using ultrasonography: the large bowel distension and a typical whirl sign - near a sigmoid colon transition point - suggested the diagnosis of sigmoid volvulus. The decision to refer the patient for emergency laparotomy was adopted without any ionizing radiation exposure, and the pre-operative diagnosis was confirmed after surgery. Sigmoid volvulus complicating pregnancy is a rare, non-obstetric cause of abdominal pain.
Original Research Article
Dec. 22, 2019
Gold Nanoparticles Targeting Human Cervical Cancer Cells
Hayat Awadh Merkadh, Fatimah Mezaal Hameed
Page Numbers : 308-311
DOI : 10.36348/sijog.2019.v02i12.003
The most disturbing gynecologic malignancies are cervical cancer particularly in the developing world with the same high incidence in Iraqi women. Cervical carcinoma has a high rate of mortality. The high death rate is associated with presence of human papillomavirus (HPV) infection. Cervical carcinoma is hard to treat, and conventional therapies are very aggressive which lead for the need for new approaches of therapy. Nanoparticles is a promising treatment modality to produce non-toxic and efficient cancer therapy. Gold nanoparticles (AuNPs) accumulate in cancer cells selectively. The current work was aimed to study cytotoxicity and cell death induced by AuNPs on cervical carcinoma cells. Methods: Cytotoxicity of AuNPs was assessed by MTT viability assay and analysed using multiple comparison ANOVA tests. Results: AuNPs nanoparticles from 12.5 up to 50 µg/mL for 72 hours showed concentration-dependent killing activity. Conclusion: Gold nanoparticles have anti-cervical carcinoma cells activity by cell death induction.
Original Research Article
Dec. 17, 2019
Vitamin D Status in Pregnant Women of North East India and Impact of Vitamin D Deficiency in Pregnancy on Feto-Maternal Outcome
Dr. Ratna Kanta Talukdar, Dr. Shweta M. Joshi
Page Numbers : 298-303
DOI : 10.36348/sijog.2019.v02i12.001
Background: Despite of sufficient and stable sunny conditions across the equatorial countries, there has been a high prevalence of Vitamin D deficiency (VDD) in pregnancy. The reasons for increased prevalence of VDD are increased time spent indoors, dark skin, and adoption of covered clothing due to religious & cultural reasons, low socio-economic status that leads to chronically poor diet. The present study was undertaken to find Vitamin D deficiency in the pregnant women of North East India and to find the adverse feto-maternal outcomes associated with VDD. Methods: This prospective study was conducted in the Department of Obstetrics & Gynaecology, Gauhati Medical College & Hospital, Guwahati, Assam, and India over a period of one year. Sample size was 150 pregnant women attending antenatal clinic. Results: Out of 150 pregnant women 66 (44%) had deficient, 41 (27.3%) had insufficient and 43 (28.7%) had sufficient vitamin D levels. VDD was seen in extremes of age groups i.e. group ≤ 20 years and 31- 35 years. Multiparity and low socio-economic status was associated with vitamin D deficiency and insufficiency, no association was found between VDD and religion (Hindu & Muslim). There was significant association between Vitamin D deficiency and insufficiency and occurrence of gestational hypertensive diseases and low birth weight babies. Rate of primary caesarean section was significantly high in vitamin D deficient women. No association was found between VDD and PROM/PPROM, preterm births, gestational diabetes mellitus and neonatal jaundice.
Original Research Article
Dec. 30, 2019
Breast Cancer in Young Women under 40 years: Epidemiological, Clinical, Therapeutic and Prognostic Aspects in the Oncology and Radiotherapy Department of Marrakech; About 318 Cases
K. Mazouz, S. Elouarzzazi, Y. Bouchabaka, D. Nimbuna, Z. Kaitoni, A. Elmatlini, M. Laanigri, M. Saadoun, M. Raouah, H. Abourazeq, S. Barkich, H. Eddaoualline, H. Sami, S. Laatitioui, M. Darfaoui, I. L
Page Numbers : 312-318
DOI : 10.36348/sijog.2019.v02i12.004
Introduction: Breast cancer in women, and especially in young women, represents a real public health issue given its frequency and severity. The objective of our study is to specify the epidemiological profile; anatomo-clinical; therapy and prognosis of breast cancer in young women. Methods: Descriptive retrospective study spread over a period of 5 years (2013-2017), collecting all the patients followed for breast cancer aged 40 years or less, within the cancer department of CHU Med VI in Marrakech. Results: The average age was 34.2 years (19-40 years). The average age at puberty was 12 years old (9 and 16 years old). Nulliparity was noted in 22% of the cases. Clinically, the T classification in the cases specified was: T1 (n = 48), T2 (n = 128), T3 (n = 52), T4 (n = 42). Clinical lymph node involvement was found in 44% of the cases. Histologically, infiltrating ductal carcinoma was the most common (n = 283). SBR II grade was the most frequent with a rate of 66%, Thirty Fifty percent of all patients had an over-expression of HER2 , Sixty-three percent had lymph node invasion, including 42% with capsular rupture and 31% of patients were metastatic in appearance. Therapeutically, fifty patients had neo-adjuvant chemotherapy. The surgery was conservative in 66% of the cases. Adjuvant chemotherapy was sequential in 61% of the cases. 180 patients had adjuvant radiation therapy. Of the 96 patients with HER2 over expression, 82 received treatment with trastuzumab. Hormone therapy was prescribed in 156 patients or 49% of cases with expression of hormone receptors. In our series, the median follow-up was 8.1 months. The course was marked by a locoregional relapse in fifty-eight patients, and a metastatic relapse in sixty patients. Conclusion: Since screening in our country does not include young women, it would be interesting to reconsider its indications, especially given the growing frequency of this cancer in young women as well as its poor prognosis.